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体内激素水平对免疫系统功能的发挥有着一定的影响。以往资料表明皮质类固醇激素有明显的免疫抑制功能,而生长激素对免疫系统的成熟也是必需的。女性自身免疫性疾病发病率提示性激素的免疫调节作用。动物实验表明雌二醇促进自身免疫病的发展,而睾酮则起相反的作用。三苯氧胺(Tamoxifen)是一种非甾类雌激素受体拮抗剂。目前已用于治疗乳腺癌,良性前列腺增生症与前列腺癌、肾癌、子宫内膜腺癌及胰腺癌,Per-golide mesylate(PGL)为类多巴胺药现用于治疗各类高催乳激素血症和柏金森氏病。本文研究发现Tamoxifen citrate(TX)与PGL具有较强的免疫调节作用。作者采用雌性Fischer和Wistar-Furth大鼠,体重为150～170克。以检测绵羊红血球(SRBC)凝集素效价及二硝基氯苯(DNCB)皮肤敏感试验来反映机体体液免疫与细胞免疫状况。实验组大鼠首先每天皮下注射TX或PGL(按
Hormone levels in the body exert a certain influence on the functioning of the immune system. Previous data show that corticosteroids have significant immunosuppressive function, and growth hormone on the immune system is also necessary. The incidence of autoimmune diseases in women suggests the immunomodulatory effects of sex hormones. Animal experiments show that estradiol promotes the development of autoimmune disease, whereas testosterone plays the opposite role. Tamoxifen is a non-steroidal estrogen receptor antagonist. Has been used to treat breast cancer, benign prostatic hyperplasia and prostate cancer, kidney cancer, endometrial adenocarcinoma and pancreatic cancer, Per-golide mesylate (PGL) is a dopamine drug is used to treat various types of hyperprolactinemia And Parkinson’s disease. This study found that Tamoxifen citrate (TX) and PGL have strong immunomodulatory effects. The authors used female Fischer and Wistar-Furth rats weighing 150-170 grams. The humoral immunity and cellular immune status of the body were detected by detecting the lectin titer of SRBC and the sensitive skin of dinitrochlorobenzene (DNCB). Rats in experimental group were injected subcutaneously with TX or PGL daily