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本研究选用7只8～18个月的恒河猴进行实验,采用钴60-γ射线照射的预处理方法使猴机体免疫力低下,再感染HFRS病毒,造成HFRS病毒感染和复制该病致病动物模型,其症状类似病人临床体征。从实验组猴体内检出了HFRS病毒抗原和特异性抗体,证实已受感染;在临床上出现了某些症状,在感染病毒第3天出现发热,体温最高可达41℃,发热持续8天;感染病毒后第6～20天出现少尿,24上尿量为10～35ml;血小板下降显著;病理学检查证实感染HFRS的恒河猴同HFRS病人的病理损伤相似。
In this study, 7 monkeys aged 8 to 18 months were selected for experiment. Pretreatment with 60Co γ-rays led to the low immunocompetence of the monkeys and subsequent infection with the HFRS virus, resulting in the infection of the HFRS virus and the replication of the disease Animal models whose symptoms are similar to the patient’s clinical signs. HFRS virus antigens and specific antibodies were detected in the experimental group of monkeys, which confirmed that they had been infected. Some symptoms appeared clinically. Fever occurred on the third day after the virus was infected. The body temperature reached 41 ° C and the fever sustained for 8 days ; 6 to 20 days after infection with oliguria, 24 on the urine volume of 10 ~ 35ml; platelet decreased significantly; pathological examination confirmed that rhesus HFRS infection in patients with HFRS pathological damage similar.