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本实验采用肠淋巴管引流术,在失血性休克大鼠模型的基础上,观察高渗盐水治疗失血性休克过程中肠淋巴流量及其蛋白含量的变化,旨在探讨高渗盐水对失血性休克大鼠治疗的淋巴机制。结果表明,休克大鼠输入高渗盐水或生理盐水后,两组大鼠的血压、肠淋巴流量及其蛋白输出量均比休克期明显升高,高渗盐水治疗组显著高于生理盐水对照组(P<0.01),而且治疗组大鼠肠淋巴流量及其蛋白输出量远远高于休克前水平(P<0.01)。结果提示,高渗盐水的抗休克机制可能与其恢复休克大鼠的淋巴流量及其蛋白输出量、改善休克时肠淋巴循环障碍有关。
In this study, intestinal lymphatic drainage was used. Based on the hemorrhagic shock model in rats, the changes of intestinal lymphatic flow and its protein content during hemorrhagic shock were observed. The aim was to investigate the effects of hypertonic saline on hemorrhagic shock Rat treatment of the lymphatic mechanism. The results showed that the blood pressure, intestinal lymph flow and protein output of rats in shock group were significantly higher than those in shock stage after being infused hypertonic saline or saline, significantly higher than that of saline control group (P <0.01). The intestinal lymphatic flow and protein output in the treatment group were much higher than those before shock (P <0.01). The results suggest that anti-shock mechanism of hypertonic saline may be related to its ability to restore lymphatic flow and its protein output in shock rats and to improve the intestinal lymph node circulation disorder in shock.