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目的观察小剂量抗抑郁药辅助治疗老年不稳定心绞痛的疗效。方法选择179例已确诊的不稳定心绞痛患者做常规和动态心电图检查后,抑郁状态的诊断抑郁自评量表(SDS),得分50分以上者102人入组,再把抑郁反应组随机分成抗抑郁治疗组(53例)及对照组(49例)。对照组执行常规不稳定性心绞痛的药物治疗,治疗组在常规治疗基础上加抗抑郁治疗,马普替林12.5mg2次/d(中午、睡前服),随访8周。结果治疗组与对照组比较,心肌缺血明显改善(P<0.05),心绞痛发作次数降低(P<0.05)。结论对不稳定性心绞痛伴抑郁情绪的老年患者行小剂量抗抑郁药治疗比常规心绞痛治疗疗效好。
Objective To observe the efficacy of low-dose antidepressants in the treatment of unstable angina in the elderly. Methods 179 patients with unstable angina pectoris who had been diagnosed undergoing routine and ambulatory electrocardiogram examination were selected. Depression status self-rating depression scale (SDS), 102 people who score more than 50 were enrolled in the study. Randomly divided into two groups Depression treatment group (53 cases) and control group (49 cases). The control group was treated with conventional unstable angina pectoris. The treatment group was given antidepressant therapy on the basis of routine treatment. Mapurate was given 12.5 mg twice a day (at noon and before going to bed) for 8 weeks. Results Compared with the control group, the myocardial ischemia was significantly improved (P <0.05) and the number of angina attacks was decreased (P <0.05). Conclusion Elderly patients with unstable angina pectoris and depression mood are better than the conventional angina pectoris in the treatment of low-dose antidepressants.