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Intrinsic and acquired drug resistance is a common problem causing the recurring of malignant tumors, such as breast and liver cancers[1,2]Successful chemotherapy is often limited due to significant side effects and development of drug resistance[3].With the rapid development of nanotechnology, over-coming drug resistance and improving the efficacy of antitumor drugs with scalable and biocompatible nanothera-pies have been extensively explored.