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该实验研究用了2,920只动物(小鼠、大鼠、豚鼠),以通用的毒理学方法,对铂和铂族金属化合物做了全面毒理研究。 研究结果表明,粒子为1～5微米的高分散性铂族金属粉末,可致动物急性和慢性中毒。大鼠经口致死剂量大于129微克原子/公斤,大鼠一次经口染毒,发现胃肠道粘膜渐进性坏死,肝细胞颗粒营养不良和肾曲管的混浊肿胀。50毫克/公斤剂量的铂、钯粉末可致大鼠慢性中毒,其主要表现是:体重增长缓慢,凝血酶元时间缩短,血清尿素和β—脂蛋白含量降低,实验末期血清白蛋白增多,尿比重降低,尿中氯化物含量异常。未见形态学改变。铂、钯金属粉末致大鼠的机能失调程度大致相同。这证明它们的作用机理有相同之处。这些
This experimental study used 2,920 animals (mouse, rat, guinea pig) to conduct a comprehensive toxicological study of platinum and platinum group metal compounds using a general toxicological approach. The results show that particles of 1 to 5 microns highly dispersed platinum group metal powder can cause acute and chronic poisoning. Rat oral lethal dose greater than 129 micrograms atom / kg, a rat oral exposure, found progressive gastrointestinal mucosal necrosis, hepatocyte dystrophy and turbid swelling of renal tubules. 50 mg / kg dose of platinum, palladium powder can cause chronic poisoning in rats, its main manifestations are: slow weight gain, shortened prothrombin time, serum urea and β-lipoprotein levels decreased end of serum albumin, urine, urine Decreased proportion, abnormal chloride content in urine. No morphological changes. Platinum, palladium metal powder caused roughly the same degree of dysfunction in rats. This proves that their mechanism of action is similar. These ones