在外原性精胺存在下,多胺和多胺氧化酶相互作用的产物能阻止淋巴细胞增殖反应,从而能抑制免疫反应,这表明它是一种自然免疫调节因子。Gunga和Porta等已证明:人胎盘中富含多胺氧化酶。作者在材料中指出:妊娠期多胺氧化酶活性增加,在胎盘绒毛间血循环中可达很高水平。 In the presence of exogenous spermine, the product of the interaction of the polyamine with the polyamine oxidase prevents the lymphocyte proliferation response, thereby inhibiting the immune response, suggesting that it is a natural immunomodulatory factor. Gunga and Porta et al have demonstrated that human placenta is rich in polyamine oxidase. The authors point out in the material: Polyamine oxidase activity increases during pregnancy, reaching a high level in the placental villus intervertebral circulation.