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肝性脑病患者常有血浆支链氨基酸(如缬氨酸、亮氨酸及异亮氨酸)浓度相对降低,而芳香氨基酸(如酪氨酸和苯丙氨酸)的浓度相对增高。照理,在这种情况下应用支链氨基酸含量高、芳香氨基酸含量低的溶液可改善病况,但若干研究结果出入颇大。本文旨在观察和比较支链氨基酸混合液及葡萄糖对肝硬化合并肝性脑病患者的治疗效果。65例患者被随机分成两组:32例(氨基酸组)每天接受8%(W/V)氨基酸溶液(含40%支链氨基酸)12.5毫升/公斤治疗,即每天氨基酸1克/公斤;33例(葡萄糖组)每天接受8%葡萄糖溶液12.5毫升/公斤,
In patients with hepatic encephalopathy, the concentrations of plasma branched-chain amino acids such as valine, leucine and isoleucine are relatively decreased while the concentrations of aromatic amino acids such as tyrosine and phenylalanine are relatively increased. Reasonable, in this case the application of branched-chain amino acids, aromatic amino acids low solution can improve the condition, but a number of findings vary considerably. This article aims to observe and compare the branched-chain amino acid mixture and glucose in patients with cirrhosis and hepatic encephalopathy treatment. Sixty-five patients were randomized into two groups: 32 (amino acid group) received 12.5 mg / kg of 8% (w / v) amino acid solution daily with 1 g / kg of amino acids per day and 33 (Glucose group) received 12.5 ml / kg of 8% glucose solution daily,