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目的分析2型糖尿病(2DM)合并骨质疏松(OP)患者骨量及血清瘦素、骨代谢指标。方法连续选择近期就诊的37例2DM合并OP患者、41例单纯OP患者和28例同龄、同性别及正常骨密度(BMD)的健康体检者(对照组),三组对象接受了腰椎L1～L4BMD、左侧股骨颈BMD、血清瘦素(LEP)、骨钙素(BGP)和碱性磷酸酶(AKP)等指标测定。结果 2DM合并OP组的腰椎L1～L4及股骨颈BMD、外周血LEP浓度明显低于单纯OP患者和对照组,而血清BGP和AKP浓度则明显高于后两者(P均<0.01～0.05)。结论 2DM合并OP患者存在着较明确骨量减少及血清LEP低水平表达,但骨转换指标活跃。
Objective To analyze the bone mass, serum leptin and bone metabolism in patients with type 2 diabetes mellitus (2DM) and osteoporosis (OP). Methods A total of 37 patients with 2DM with OP, 41 patients with OP and 28 healthy subjects with the same age, same sex and normal BMD (control group) were enrolled in the study. The three groups of patients received L1 ~ L4BMD Left femoral neck BMD, serum leptin (LEP), osteocalcin (BGP) and alkaline phosphatase (AKP). Results The levels of LEP in peripheral blood of 2DM patients with OP and lumbar vertebra L1 ~ L4 and femoral neck BMD were significantly lower than those of patients with OP alone and control group, while serum BGP and AKP levels were significantly higher than those of the latter two (all P <0.01-0.05) . Conclusions There is a definite osteopenia and a low serum LEP expression in 2DM patients with OP, but the indexes of bone turnover are active.