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[目的]探讨骨桥蛋白(OPN)的表达与青年妇女宫颈鳞癌浸润转移的关系。[方法]采用免疫组化和原位杂交方法检测92例青年妇女宫颈组织骨桥蛋白及其mRNA的表达,其中正常宫颈鳞状上皮(NCE)28例,浸润性鳞状细胞癌(ISCC)64例。[结果]OPN及其mRNA在ISCC中的阳性表达显著强于NCE的阳性表达(P<0.05);其表达在不同分化程度、临床分期、浸润深度、转移状态的肿瘤之间有显著差异性。[结论]OPN的过度表达在青年妇女宫颈鳞癌浸润和转移中可能起重要作用,OPN可作为判断青年妇女宫颈鳞癌浸润、转移及预后的参考指标之一。
[Objective] To explore the relationship between osteopontin (OPN) expression and infiltration and metastasis of cervical squamous cell carcinoma in young women. [Methods] The expression of osteopontin and its mRNA in cervical tissue of 92 young women were detected by immunohistochemistry and in situ hybridization. Among them, 28 cases of normal cervical squamous epithelium (NCE), invasive squamous cell carcinoma (ISCC) 64 example. [Results] The positive expression of OPN and its mRNA in ISCC was significantly higher than that in NCE (P <0.05). The expression of OPN and its mRNA was significantly different between tumors with different degrees of differentiation, clinical stage, depth of invasion and metastasis. [Conclusion] Overexpression of OPN may play an important role in the infiltration and metastasis of cervical squamous cell carcinoma in young women. OPN can be used as a reference index to determine the infiltration, metastasis and prognosis of cervical squamous cell carcinoma in young women.