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目的观察急性冠脉综合征(ACS)患者外周血中基质金属蛋白酶-9(MMP-9)及超敏C反应蛋白(hsCRP)的水平变化。方法选取110例ACS患者,以40例非ACS患者作为对照组,采用酶联免疫法(ELISA)测定血清MMP-9的水平,采用免疫比浊法定量检测hsCRP。结果ACS组MMP-9、hsCRP水平显著高于对照组分别为〔(14.25±3.51)和(11.14±2.23)ng/ml,P<0.01;(4.32±2.41)和(0.23±0.11)mg/100 ml,P<0.01〕。结论急性冠脉综合征患者存在明显的炎性反应,MMP-9和hsCRP的高表达可佐证急性冠脉综合征。
Objective To observe the changes of the levels of matrix metalloproteinase-9 (MMP-9) and hsCRP in peripheral blood of patients with acute coronary syndrome (ACS). Methods One hundred and ten patients with ACS were enrolled in this study. Forty non-ACS patients were enrolled as control group. Serum MMP-9 levels were measured by enzyme-linked immunosorbent assay (ELISA) and hsCRP was quantified by immunoturbidimetry. Results The levels of MMP-9 and hsCRP in ACS group were significantly higher than those in control group [(14.25 ± 3.51) and (11.14 ± 2.23) ng / ml, respectively, P <0.01 vs (4.32 ± 2.41) and (0.23 ± 0.11) mg / 100 ml, P <0.01〕. Conclusion There is a significant inflammatory response in patients with acute coronary syndrome. The high expression of MMP-9 and hsCRP may support acute coronary syndrome.