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AIM:To evaluate the association of pre-treatment ~(13)C-ureabreath test (UBT) results with H pylori density and efficacyof eradication therapy in patients with active duodenalulcers.METHODS:One hundred and seventeen consecutiveoutpatients with active duodenal ulcer and H pylori infectionwere recruited.H pylori density was histologically gradedaccording to the Sydney system.Each patient receivedlansoprazole (30 mg b.i.d.),clarithromycin (500 mg b.i.d.)and amoxicillin (1 g b.i.d.) for 1 week.According to pre-treatmentUBT values,patients were allocated into low (<16‰),intermediate (16-35‰),and high (>35‰) UBT groups.RESULTS:A significant correlation was found betweenpre-treatment UBT results and H pylori density (P<0.001).H pylori eradication rates were 94.9%,94.4% and 81.6%in the low,intermediate and high UBT groups,respectively(per protocol analysis,P=0.11).When patients wereassigned into two groups (UBT results≤35‰ and >35‰),the eradication rates were 94.7% and 81.6%,respectively(P=0.04).CONCLUSION:The intraclastric bacterial load of H pylorican be evaluated by UBT,and high pre-treatment UBTresults can predict an adverse outcome of eradicationtherapy.
AIM: To evaluate the association of pre-treatment ~ (13) C-urethane test (UBT) results with H pylori density and efficacy of eradication therapy in patients with active duodenal ulcers. METHODS: One hundred and seventeen consecutive patients with active duodenal ulcer and H pylori accredited to pre-treatmentUBT values, patients were allocated UBT groups. RESULTS: A significant correlation was found between pre-treatment UBT results and H pylori density (P <0.001). H pylori (P <0.001) The eradication rates were 94.9%, 94.4% and 81.6% respectively in the low, intermediate and high UBT groups, respectively (per protocol analysis, P = 0.11) .When patients were assigned into two groups (UBT results≤35 ‰ and> 35% o) the eradication rates were 94.7% and 81.6%, respec tively (P = 0.04). CONCLUSION: The intraclastric bacterial load of H pylorican be evaluated by UBT, and high pre-treatment UBTresults can predict an adverse outcome of eradication therapy.