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急性中耳炎为儿童最多见感染疾患之一,如不及时使用适当的抗生素治疗常会发生合并症,所以了解其病原微生物感染的频率及其对药物的敏感性是很重要的。在日本原认为金黄色葡萄球菌是主要的病原菌,但有的国家报道却以其他病菌为主,如美国的报道认为流感嗜血杆菌和肺炎链球菌是儿童中耳炎的主要病原体。日本之所以认为最重要的病原是金黄色葡萄球菌,是因在中耳炎的耳溢液中最常分离出此菌,但这些培养物大多是取自耳溢液而不是从病变原发部位取得的。1977年Takayama通过鼓膜切开术后所作的培养结果,首先强调了肺炎链球菌和流感嗜血
Acute otitis media is one of the most common infectious diseases in children. Complications often occur if inappropriate antibiotics are not used in time, so it is important to understand the frequency of their pathogenic microbial infections and their susceptibility to drugs. In Japan, Staphylococcus aureus was originally considered to be the major pathogen, but other countries reported mainly other pathogens. For example, U.S. reports that H. influenzae and S. pneumoniae are the major pathogens of otitis media in children. The reason why Japan thinks the most important pathogen is Staphylococcus aureus is that it is most often isolated from the otitis media effusion. However, most of these cultures are derived from the ear fluid rather than from the primary site of the lesion . Takayama passed the tympanotomy in 1977 after the results of the culture, the first to emphasize the pneumococcal and flu bloodthirsty