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尽管嗜肝性作为乙型肝炎病毒(HBV)的生物学活性之一已得到公认,并且HBV归属于肝DNA病毒科(HAPADNAVIRIDAE),但近年来的一些动物实验和临床研究表明:除了肝细胞之外,还可在其它组织中检测到HBV抗原和DNA,包括它的复制形式。这对于研究HBV感染的慢性持续状态、受染者的免疫异常、及感染的传播途径等具有一定价值。为此,我们采用Southern blot杂交技术,对11例乙肝及肝癌患者的尸解多种组织进行了
Although hepatic hepatopathy has been recognized as one of the biological activities of hepatitis B virus (HBV), and HBV belongs to the genus Hapadavirus, some animal experiments and clinical studies in recent years have shown that in addition to hepatocytes In addition, HBV antigens and DNA can be detected in other tissues, including its replicative form. This is of some value for studying the chronic persistence of HBV infection, immune abnormalities in infected persons, and the route of transmission of infection. To this end, we used Southern blot hybridization of 11 cases of hepatitis B and liver cancer in patients with a variety of organizations were