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目的:观察不同剂量氟哌啶醇对新西兰兔心电图QT间期、PR间期以及QRS波群的影响。方法:采用体表心电图技术,观察不同剂量氟哌啶醇对新西兰兔心电图的影响,通过BL-410生物机能实验系统动态记录Ⅱ导联心电图的变化。结果:氟哌啶醇能引起的QT间期延长、PR间期延长以及QRS波群变宽,剂量越大延长越明显。1 mg/kg、2 mg/kg氟哌啶醇能延长QT间期,但对PR间期以及QRS波群的影响无统计学意义;4 mg/kg氟哌啶醇能明显延长QT间期、PR间期,同时使QRS波群明显增宽。氟哌啶醇对QT间期的影响主要发生在给药后0～120 min,360 min后基本恢复正常;对PR间期以及QRS波群的影响主要发生在给药后0～30 min,30 min后基本恢复正常。结论:氟哌啶醇可使QT间期延长,随着剂量的增加,能明显延长PR间期,导致QRS波群增宽,从而增加发生室性心律失常的潜在危险性。
OBJECTIVE: To observe the effects of different doses of haloperidol on QT interval, PR interval and QRS complex in ECG in New Zealand rabbits. Methods: Electrocardiogram (ECG) was used to observe the effect of different doses of haloperidol on ECG in New Zealand rabbits. The change of electrocardiogram of Ⅱ lead was recorded dynamically by BL-410 biological function test system. RESULTS: Haloperidol could prolong the QT interval, prolong the PR interval and widen the QRS complex. The greater the dose, the longer the extension. 1 mg / kg, 2 mg / kg haloperidol prolonged the QT interval, but had no significant effect on the PR interval and QRS complex; 4 mg / kg haloperidol significantly prolonged the QT interval, PR interval, while making QRS wave group significantly wider. The effects of haloperidol on QT interval mainly occurred at 0-120 min after administration and returned to normal after 360 min. The effects on PR interval and QRS complex mainly occurred at 0-30 min after administration After the basic return to normal. CONCLUSION: Haloperidol prolongs the QT interval, and prolongs the PR interval with the increase of dose, resulting in widening of the QRS wave group and increasing the potential risk of ventricular arrhythmia.