目的观察对慢性阻塞性肺疾病(COPD)急性加重期的患者采用震动排痰与雾化吸入联合疗法进行治疗的临床疗效。方法 120例临床确诊的慢性阻塞性肺疾病急性加重期患者,随机分为对照组和观察组,各60例。对照组采用复方异丙托溴铵溶液雾化吸入治疗,观察组采用震动排痰与复方异丙托溴铵溶液雾化吸入联合疗法治疗。比较两组治疗前后的症状、体征等改善情况;分析评价两组的治疗效果;观察两组患者治疗前后的血气指标变化及不良反应。结果观察组临床症状及体征迅速改善,与对照组比较差异有统计学意义(P<0.05);观察组患者的血气指标改善情况明显优于对照组患者(P<0.05);两组患者治疗期间均未出现明显的不良反应。结论慢性阻塞性肺疾病急性加重期的患者应用震动排痰与雾化吸入联合疗法的疗效肯定,可以明显促进症状的缓解及体征的恢复。 Objective To observe the clinical effect of combined treatment of vomiting sputum and atomizing inhalation on patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 120 patients with clinically diagnosed chronic obstructive pulmonary disease were randomly divided into control group and observation group, with 60 cases in each. The control group was treated with compound ipratropium bromide solution atomization inhalation. The observation group was treated with combination of vibration and expectoration with compound ipratropium bromide atomizing inhalation. The improvement of symptoms and signs before and after treatment were compared between the two groups. The curative effect of the two groups was analyzed and evaluated. The changes of blood gas indexes and adverse reactions before and after treatment were observed. Results The clinical symptoms and signs of the observation group improved rapidly with a significant difference from the control group (P <0.05). The improvement of blood gas indexes in the observation group was significantly better than that of the control group (P <0.05) No obvious adverse reactions occurred. Conclusion Patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) have a positive effect of combination of vibration and sputum aspiration therapy and nebulized inhalation therapy, which can significantly promote the relief of symptoms and signs.