新生儿的生理状况与婴幼儿不同,其药物代谢动力学状况常易发生变化,特别是患有感染的新生儿,因此选择安全有效的抗生素尤为重要。要求:临床药师根据新生儿药代动力学的特点,为新生儿应用抗生素提供临床用药评价与建议: 1 评价 1.1 青霉素类青霉素治疗新生儿感染已有50多年的历史,不良反应较少,但过敏性休克是其最严重的问题,发生率为0.004％—0.015％,死亡率为 Physiological conditions of newborns and infants and young children is different, its pharmacokinetic status is often changed, especially with infected newborns, so choose safe and effective antibiotics is particularly important. Requirements: clinical pharmacists according to the characteristics of neonatal pharmacokinetics for neonatal antibiotics to provide clinical evaluation and recommendations: 1 evaluation penicillin penicillin for neonatal infection has been 50 years of history, less adverse reactions, but allergic Sex shock is its most serious problem, the incidence was 0.004% -0.015%, the mortality rate was