对食管上皮细胞正常（以下简称正常）、食管上皮细胞轻度增生（以下简称轻度增生）和食管上皮细胞重度增生（以下简称重度增生）共46161例进行了癌变时间和癌变率的研究结果说明：食管癌变平均时间的频率差异为重度增生癌变平均时间3年7月＜轻度增生癌变平均时间5年4月＜食管正常癌变平均时间8年10月。食管癌变率的频率差异为重度增生癌变率38．9％＞轻度增生癌变率5．8％＞正常癌变率1．4％。 A total of 46,161 cases of normal esophageal epithelial cells (hereinafter referred to as normal), mild hyperplasia of esophageal epithelial cells (hereinafter referred to as mild hyperplasia), and severe hyperplasia of esophageal epithelial cells (hereinafter abbreviated as severe hyperplasia) were investigated for the time and rate of canceration. : The average frequency of esophageal carcinogenesis varies with the average time of severe hyperplastic carcinoma, 3 years, 7 months, and the average time of mild hyperplastic carcinoma, 5 years, 4 months. The average duration of esophageal cancer is 8 years and 10 years. The frequency of esophageal cancer variability was 38.9% for severe hyperplasia, 5.8% for mild hyperplasia, and 1.4% for normal cancer.