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目的研究帕屈磷酸钠对Ｗ２５６肿瘤引起大鼠骨溶解作用的影响。方法除正常组以外，每鼠右后肢胫骨上端骨旁肌肉内注入０．２ｍｌＷ２５６瘤细胞悬液（４×１０６个瘤细胞），ｄ１２可引起大鼠局部骨组织溶解、破坏及血钙和钙排泄增加等变化。结果帕屈磷酸钠（ＡＰＤ，７．５、１５与３０ｍｇ·ｋｇ－１），一次性尾静脉注射对Ｗ２５６性溶骨大鼠的血钙和尿钙升高以及骨矿含量的降低均有明显的防治作用，经ＰＯＳ型显微光密度仪对鼠股骨和胫骨Ｘ光片扫描分析的结果表明，ＡＰＤ（３０ｍｇ·ｋｇ－１）对Ｗ２５６引起的大鼠骨密度降低也有明显的防治作用。结论帕屈磷酸钠对Ｗ２５６引起的大鼠溶骨及并发症具有良好的防治作用。
Objective To investigate the effects of sodium pamfonate on the osteolysis induced by W256 tumor in rats. Methods In addition to the normal group, 0.2ml W256 tumor cell suspension (4 × 106 tumor cells) was infused into the periosteal muscle of right hind paw in the right hindlimb of each rat. D12 can cause the local bone tissue to dissolve and destroy, as well as the excretion of calcium and calcium Increase and other changes. Results One-time tail vein injection of sodium polyharfose phosphate (APD, 7.5, 15 and 30 mg · kg-1) significantly increased the blood calcium and urinary calcium and the bone mineral content in W256 osteolytic rats The results of scanning electron microscopy (SEM) and scanning electron microscopy (SEM) showed that APD (30mg · kg-1) also had a significant preventive and therapeutic effect on the reduction of bone mineral density induced by W256 in rats. Conclusion Sodium pafopexate has a good preventive and therapeutic effect on W256-induced osteolytic and complications in rats.