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目的:探讨细胞核DNA倍体类型与胃癌预后的关系。方法:应用流式细胞仪(FCM)测定石蜡包埋的胃癌组织细胞核中DNA倍体类型,同时进行生存期随访及观察癌灶周围组织中小静脉、毛细淋巴管癌浸润情况。结果:50例胃癌,二倍体16例(32.0％),异倍体34例(68.0％)。二倍体和异倍体的5年生存率(5-YRS)分别为50.0％、17.6％,癌灶周围小静脉浸润率二倍体和异倍体分别为37.5％和70.6％,淋巴管浸润率二倍体和异倍体分别为43.8％、85.3％。结论:具异倍体的胃癌较二倍体的易发生浸润和转移、预后差,测定DNA倍体模式在评估胃癌预后上有重要作用。
Objective: To investigate the relationship between nuclear DNA ploidy and prognosis of gastric cancer. METHODS: Flow cytometry (FCM) was used to determine the DNA ploidy in paraffin-embedded tissues of gastric cancer. At the same time, follow-up of survival period and observation of infiltration of small veins and lymphatic capillaries around the tumor tissue were performed. Results: There were 50 gastric cancers, 16 diploids (32.0%), and 34 aneuploids (68.0%). The 5-year survival rates (5-YRS) of diploid and aneuploid were 50.0% and 17.6%, respectively. The diploid and aneuploid infiltration rate around the tumor was 37.5% and 70.6%, respectively, and the lymphatic vessels were infiltrated. The rate of diploid and aneuploid were 43.8% and 85.3%, respectively. Conclusion: The heteroploid gastric cancer is more prone to invasion and metastasis than the diploid, and the prognosis is poor. The determination of DNA ploidy model plays an important role in evaluating the prognosis of gastric cancer.