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近年来,在恶性肿瘤治疗中抗癌药化疗仍为常用方法,延长了许多患者的生命。但是发现这些药物特别是烷化剂,可引起严重的远期并发症,即继发急性非淋巴细胞白血病(S-ANLL)和/或第二肿瘤,晚近亦有人称前者为治疗相关性白血病(t-ANLL)。S-ANLL及其白血病前期(PL)已严重威胁肿瘤患者成功化疗后的长期生存,因而日益引人瞩目。在何杰金病(HD)、非何杰金淋巴瘤(NHL)、真性红细胞增多症(PLV)、多发性骨髓瘤(MM)、慢性淋巴细胞
In recent years, anticancer drug chemotherapy remains a commonly used method in the treatment of malignant tumors, extending the lives of many patients. However, the discovery of these drugs, especially alkylating agents, can cause serious long-term complications, secondary to acute non-lymphocytic leukemia (S-ANLL) and / or secondary tumor, and the latter has recently been described as treatment-related leukemia t-ANLL). S-ANLL and its pre-leukemia (PL) have been a serious threat to the long-term survival of cancer patients following successful chemotherapy and have therefore drawn increasing attention. In Hodgkin’s disease (HD), non-Hodgkin lymphoma (NHL), polycythemia vera (PLV), multiple myeloma (MM), chronic lymphocytic