美《医学世界新闻》第20卷第22期(1979年)报道:一名10岁儿童患病3日,类似流感,因昏迷而住院.检查:血糖600毫克/分升。一周后,因糖尿病酮症酸中毒及脑水肿而死亡。尸检发现胰岛有炎症性损坏,大量β细胞坏死。死者胰腺冰冻标本经病理检查,从胰岛中分离出柯萨奇B4病毒,将病毒注射于小鼠后,小鼠胰岛迅速损害,发生酮症酸中毒。 Medical World News Vol. 20, No. 22 (1979) Reported: A 10-year-old child was sick on the 3rd, flu-like, hospitalized in a coma. Examination: Blood sugar 600 mg / dL. One week later, he died of diabetic ketoacidosis and cerebral edema. Autopsy found that islets have inflammatory damage, a large number of β-cell necrosis. Frozen pancreatic frozen specimens by pathological examination, isolated from the islets of Coxsackie B4 virus, the virus injected in mice, the mouse islet rapidly damaged ketoacidosis.