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目的:评价呼气末二氧化碳（ETCOn 2）在自发性脑出血术后机械通气患者被动抬腿（PLR）试验预测容量反应性中的应用价值及安全性。n 方法:入选自发性脑出血术后行机械通气需液体复苏的患者33例，先后进行PLR试验和补液试验，记录心排量（CO）、每搏输出量（SV）、平均动脉压（MAP）及ETCOn 2等指标。以补液试验后CO增加≥10%为有反应组，CO增加<10%为无反应组，记录两组临床资料、试验前后CO、SV及ETCOn 2变化趋势。使用受试者工作特征（ROC）曲线分析各指标对容量反应性的预测价值。比较两组PLR及补液前后颅内压（ICP）变化。n 结果:33例患者分为有反应组16例，无反应组17例。PLR后、补液后有反应组MAP变化值、CO变化值、SV变化值、ETCOn 2变化值、CO变化率、ETCOn 2变化率均高于无反应组（均n P0.05）。n 结论:PLR后ETCOn 2变化率可作为预测自发性脑出血术后机械通气患者容量反应性的简便、可靠的无创性指标，且安全可行。n “,”Objective:To evaluate the use and safety of end-tidal carbon dioxide (ETCOn 2) in predicting volume responsiveness in the passive leg raising (PLR) test of mechanically ventilated patients after spontaneous cerebral hemorrhage.n Methods:Thirty-three patients, who underwent mechanical ventilation and required fluid resuscitation after cerebral hemorrhage, were included in the study. The PLR test and fluid challenge test were performed successively, and the indexes such as cardiac output (CO) , stroke volume (SV) , mean arterial pressure (MAP) and ETCOn 2 were recorded. After the fluid challenge test, the patients with CO increased by ≥10% were included in the responsive group, whereas the patients with CO increased by <10% was included in the non-responsive group. The clinical data and the change trends in CO, SV and ETCO n 2 before and after the test in the two groups were recorded. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of the indexes on the volume responsiveness. The changes in intracranial pressure (ICP) before and after PLR test and fluid challenge test were compared between the two groups.n Results:Thirty-three patients were divided into the responsive group (n n=16) and non-responsive group (n n=17) , respectively. After the PLR test and fluid challenge test, the change levels of MAP, CO, SV and ETCOn 2, and the change rate of CO and ETCOn 2 in the responsive group were higher than those in the non-responsive group (all n P0.05) .n Conclusion:The change rate of ETCOn 2 after PLR can be used as a simple, reliable and noninvasive index for predicting the volume responsiveness of mechanically ventilated patients after spontaneous cerebral hemorrhage, and it is safe and feasible.n