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目的：探讨利塞膦酸钠（Ｒｉｓ）使用和撤药对去卵巢大鼠骨骼的影响．方法：Ｒｉｓ５μｇ·ｋｇ－１，皮下注射一周两次．胫骨上段不脱钙骨制片测量．结果：（１）去卵巢喂水组胫骨骨小梁面积三组都减少，出现骨吸收大于骨形成的骨高转化率．（２）Ｒｉｓ治疗（Ｒｉｓｏｎ）的去卵巢组与（１）比，６０，８１和１５０天，骨小梁的面积分别增加（２１７％，１０８％和１０１％），并降低骨高转化率至对照组．与６０，８１天组比，１５０天组不能维持较高的骨量．（３）用Ｒｉｓ６０天，撤药观察，２１天时与（Ｒｉｓｏｎ）组无差异，９０天时骨小梁面积增高（＋２６％），并超过年龄对照组（＋２７％）．结论：Ｒｉｓ使用／撤药的方案对去卵巢大鼠有预防骨质疏松的作用．
Objective: To investigate the effect of risedronate sodium (Ris) on the bone of ovariectomized rats. Methods: Ris5μg · kg-1, subcutaneous injection twice a week. Upper tibia non-decalcified bone slices measured. Results: (1) The tibial trabecular area of the ovariectomized group decreased in all three groups, and bone resorption was higher than that of the bone formation in the ovariectomized group. (2) In the Ris-ovariectomized ovariectomized group, the trabecular area increased by 217%, 108%, and 101%, respectively, at the ratio of 60, 81 and 150 days (1) Rate to the control group. Compared with the 60 and 81 day groups, the 150-day group could not maintain a higher bone mass. (3) Observed 60 days after Ris withdrawal, there was no difference between (Ris-on) at 21 days and increased trabecular area (+ 26%) at 90 days and exceeded the age control group (+ 27%). Conclusion: Ris use / withdrawal protocol can prevent osteoporosis in ovariectomized rats.