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[目的 ] 通过测定某大型石化企业车间环境中混苯 (苯、甲苯、二甲苯 )及工人尿液中混苯的代谢产物 ,评价工人的接触水平。 [方法 ] 选择该公司有混苯暴露的芳烃、烯烃等六个厂以及无混苯暴露的职工医院 ,用气相色谱法 (GC)测定空气中混苯 ,并用高效液相色谱法 (HPL C)法测定工人尿液中反 ,反 -粘糠酸 (t,t- MA)以及马尿酸(HA)。 [结果 ] 车间空气中苯的平均浓度波动在 0 .73～ 2 6 .91mg/ m3之间 ,最大超标率为 7.41% ,最大超标倍数为2 0 .91;混苯暴露厂工人尿液中 t,t- MA,工后明显高于工前 ,差值波动在 1.14～ 3.78ug/ mg.Cr,明显高于对照单位的 0 .33 ug/ mg.Cr,且暴露工人尿液的变化值与空气苯浓度呈等级相关性 (Rs=0 .6 4,P=0 .0 3) ;甲苯、二甲苯检出率较低 ,HA工后、工前无明显差异。 [结论 ] 该公司存在混苯暴露 ,但以低浓度苯暴露为主 ,t,t- MA可作为苯暴露的生物学监测指标
[Objective] To evaluate the contact level of workers by measuring the mixed benzene (benzene, toluene, xylene) and the metabolites of mixed benzene in the urine of workers in the workshop of a large petrochemical enterprise. [Method] Six companies such as aromatics and olefins exposed to mixed benzene and the workers’ hospital without exposure to benzene were selected. The benzene in the air was determined by gas chromatography (GC) and analyzed by high performance liquid chromatography (HPLC) Determination of workers in the urine of urine anti-anti-mucic acid (t, t-MA) and hippuric acid (HA). [Result] The average concentration of benzene in the air of workshop was fluctuated between 0. 73 ~ 26.91mg / m3, the maximum rate exceeded 7.41% and the maximum exceeded standard was 20.91. , t-MA, post-work was significantly higher than the pre-work, the difference between the fluctuations in the 1.14 ~ 3.78ug / mg.Cr, significantly higher than the control unit 0.33 ug / mg.Cr, and exposed workers urine changes and The concentration of benzene in air showed a rank correlation (Rs = 0.64, P = 0.30). The detection rates of toluene and xylene were lower, and there was no significant difference in HA after working. [Conclusion] The company has mixed benzene exposure, but mainly low benzene concentration exposure, t, t-MA can be used as biological monitoring indicators of benzene exposure