论文部分内容阅读
目的探讨氧化苦参碱(OMT)对自发性高血压大鼠(SHR)血流动力学的影响。方法 10周龄WKY为正常对照组(A组)和正常给药对照组(B组),分别灌服0.9%NaCl溶液或氧化苦参碱小剂量(30μg/g)。另取10周龄SHR,随机分为4组,每组10只:SHR对照组(C组),给予0.9%NaCl溶液;西药阳性对照组(D组),每日灌服卡托普利40μg/g;治疗组(氧化苦参碱小、大剂量组),给予氧化苦参碱30、60μg/g(E组、F组)。连续给药21周。分别于给药前1周,给药后每隔2周测定1次血压。给药结束后,导管经颈总动脉插入左心室测量左心室收缩压(LVSP)、左室舒张末期压(LVEDP)、左室收缩/舒张最大速率(±dp/dtmax)等血流动力学指标。结果与WKY正常对照组比较,WKY正常给药对照组各指标差异无统计学意义(P>0.05)。与WKY正常对照组比较,SHR对照组收缩压(SBP)、舒张压(DBP)、LVEDP升高,±dp/dtmax降低,差异有统计学意义(P<0.05);LVSP差异无统计学意义(P>0.05)。与SHR对照组比较,氧化苦参碱小、大剂量组及西药阳性对照组在给药后3～18周时SBP、DBP降低(P<0.05);氧化苦参碱大剂量组和西药阳性对照组LVSP升高,LVEDP降低(P<0.05);氧化苦参碱小、大剂量组和西药阳性对照组±dp/dtmax升高(P<0.01)。结论 OMT能降低SHR的血压,改善左心室收缩和舒张功能,对SHR心室重构、心力衰竭的发展有一定的抑制、延缓作用。
Objective To investigate the effects of oxymatrine (OMT) on hemodynamics in spontaneously hypertensive rats (SHR). Methods WKY at 10 weeks of age was given as normal control (group A) and normal control group (group B), and 0.9% NaCl or oxymatrine (30 μg / g) were orally administrated. Another 10-week-old SHR were randomly divided into four groups of 10: SHR control group (C), 0.9% NaCl solution; western medicine positive control group (D), daily captopril 40μg / g; treatment group (oxymatrine small and large dose group), given oxymatrine 30,60μg / g (E group, F group). Continuous administration for 21 weeks. Blood pressure was measured at 1 week before administration and once every 2 weeks after administration. After administration, the left ventricular catheter was inserted into the left ventricle through the common carotid arteries to measure the hemodynamic parameters such as left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), and left ventricular systolic / diastolic velocity (± dp / dtmax) . Results Compared with WKY normal control group, there was no significant difference in each index of WKY normal control group (P> 0.05). Compared with WKY normal control group, SBP, DBP, LVEDP and ± dp / dtmax in SHR control group decreased (P <0.05), while there was no significant difference in LVSP P> 0.05). Compared with SHR control group, SBP and DBP of oxymatrine small and large dose group and western medicine positive control group decreased 3 ~ 18 weeks after administration (P <0.05); high dose oxymatrine group and western medicine positive control LVSP increased and LVEDP decreased (P <0.05). ± dp / dtmax increased in oxymatrine small dose group, high dose dose group and western medicine positive control group (P <0.01). Conclusion OMT can reduce the blood pressure of SHR, improve the left ventricular systolic and diastolic function, inhibit the development of ventricular remodeling and heart failure in SHR to a certain extent.