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AIM:To study the dose-dependent of progesterone(P)effect and the interaction between the oxytocin(OT)and Pon gastrointestinal motility.METHODS:In order to monitor the gastric emptying andintestinal transit,the SD male rats were intubated via acatheter with normal saline(3 ml/kg)containing Na_2~(51)CrO_4(0.5 μCi/ml)and 10 % charcoal.OT was dissolved intonormal saline and P was dissolved into 75 % alcohol.RESULTS..Low does of P(1 mg/kg,i.p.)enhanced thegastric emptying(75±3 %,P<0.05)and high dose of P(5mg/kg,i.p.)inhibit it(42±11.2 %,P<0.01).P(1 mg/kg)increased the intestinal transit(4.2±0.3,P<0.05)whilethe higher dose(10-20 mg/kg)had no effect.OT(0.8 mg/kg,i.p.)inhibited the gastric emptying(23.5±9.8 %,P<0.01).The inhibitory effects of P(20 mg/kg)(32±9.7 %,P<0.05)and OT(0.8 mg/kg)on gastric emptying enhancedeach other when the two chemicals were administratedsimultaneously(17±9.4 %,P<0.01).CONCLUSION: Low dose of P increased Gl motility while high dose of P decreased it. During the later period of pregnancy, elevated plasma level of OT may also participate in the gastrointestinal inhibition.
AIM: To study the dose-dependent of progesterone (P) effect and the interaction between the oxytocin (OT) and Pon gastrointestinal motility. METHODS: In order to monitor the gastric emptying and intestinal transit, the SD male rats were intubated via acatheter with normal saline and P was dissolved into 75% alcohol.RESULTS. Low does of P (1 mg / kg) containing Na 2 51 CrO 4 (0.5 μCi / ml) and 10% charcoal.OT was dissolved intonormal saline and P was dissolved into 75% kg, ip) enhanced thegastric emptying (75 ± 3%, P <0.05) and high dose of P (5 mg / kg, ip) inhibit it (42 ± 11.2%, P <0.01) The intestinal transit (4.2 ± 0.3, P <0.05) had no effect. OT (0.8 mg / kg, ip) inhibited the gastric emptying (23.5 ± 9.8%, P <0.01) On inhibitory effects of P (20 mg / kg) (32 ± 9.7%, P <0.05) and OT (0.8 mg / kg) on gastric emptying enhance other other when the two chemicals were administered chemically (17 ± 9.4%, P <0.01 ) .CONCLUSION: Low dose of P increased Gl motility while high dose of P decreased it. During t he later period of pregnancy, elevated plasma level of OT may also participate in the gastrointestinal inhibition.