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目的:探究依那西普联合来氟米特治疗强直性脊柱炎(AS)的疗效及安全性。方法:收集2015年1月-2016年6月间我院收治的AS患者90例,按随机数字表法分为观察组和对照组,每组各45例。观察组采用依那西普联合来氟米特治疗,对照组则单纯采用来氟米特治疗。记录两组治疗前后的晨僵时间、AS活动性指数(BASDAI)和AS测量指数(BASMI),比较两组治疗总有效率及不良反应发生情况。结果:治疗后,两组患者晨僵时间、BASDAI及BASMI较治疗前均有所下降,且观察组上述各指标均显著低于对照组,差异有统计学意义(P<0.05);观察组总有效率显著高于对照组,差异有统计学意义(P<0.05);治疗过程中,患者发生的主要不良反应为肝功能损伤、腹泻和过敏性皮疹,但两组不良反应发生率差异无统计学意义(P>0.05)。结论:依那西普联合来氟米特可获得比较理想的疗效,且不良反应发生率较低,值得在临床上推广使用。
Objective: To investigate the efficacy and safety of Etanercept plus leflunomide in treatment of ankylosing spondylitis (AS). Methods: Ninety AS patients who were admitted to our hospital from January 2015 to June 2016 were divided into observation group and control group according to the random number table method, with 45 cases in each group. The observation group was treated with Etanercept plus leflunomide, while the control group was treated with leflunomide alone. The morning stiffness time, the AS activity index (BASDAI) and the AS measurement index (BASMI) of both groups were recorded before and after treatment. The total effective rate and adverse reactions in the two groups were compared. Results: The morning stiffness time, BASDAI and BASMI in both groups decreased after treatment, and the above indexes in the observation group were significantly lower than those in the control group (P <0.05). The total observation group The effective rate was significantly higher than the control group, the difference was statistically significant (P <0.05); the course of treatment, the main adverse reactions occurred in patients with liver dysfunction, diarrhea and allergic rash, but the incidence of adverse reactions in both groups showed no statistical difference Significance (P> 0.05). Conclusion: Etanercept combined with leflunomide can obtain more ideal curative effect, and the incidence of adverse reactions is lower, which is worth to be popularized in clinic.