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目的了解肇庆市全人群麻疹、风疹、流行性腮腺炎抗体水平,为控制相应疾病、改善免疫策略提供科学依据。方法按分层随机原则抽取肇庆市三个县区2012年全人群血清标本共319份,用酶联免疫吸附试验定量检测麻疹、风疹、流行性腮腺炎Ig G抗体水平。结果肇庆市2012年全人群麻疹抗体阳性率为88.40%、抗体几何平均浓度(Geometric Mean Concentration,GMC)为1167.95m IU/ml;风疹抗体阳性率为78.06%、GMC为146.10IU/ml;流行性腮腺炎抗体阳性率为74.92%,GMC为447.96U/ml。人群麻疹、风疹抗体阳性率在不同县区、年龄段、性别、城乡之间没有统计学差异;流行性腮腺炎抗体阳性率在城乡之间没有统计学差异,在不同县区、不同年龄段、性别之间有统计学差异(X~2=9.760,P<0.05;X~2=36.509,P<0.05;X~2=5.575,P<0.05);低龄儿童麻疹、风疹、流行性腮腺炎抗体阳性率和GMC偏低,20~29岁年龄段人群麻疹、风疹抗体阳性率和GMC不高。结论肇庆市全人群对麻疹、风疹、流行性腮腺炎疾病已建立一定的免疫屏障,但应加强对低龄儿童的预防接种工作,及时为8~11月龄儿童接种麻疹风疹联合减毒活疫苗(MR)、1.5岁以上儿童接种麻腮风联合减毒活疫苗(MMR);建议为20~29岁育龄期妇女接种MR或MMR,进一步提高全人群防病水平。
Objective To understand the levels of measles, rubella and mumps in Zhaoqing and to provide a scientific basis for controlling the corresponding diseases and improving immunization strategies. Methods A total of 319 serum samples were collected from three populations in Zhaoqing City in 2012 according to the principle of stratified randomization. Ig G antibody levels of measles, rubella and mumps were quantitatively detected by enzyme-linked immunosorbent assay. Results The positive rate of measles antibody in whole population was 88.40% in 2012 in Zhaoqing City. The Geometric Mean Concentration (GMC) was 1167.95m IU / ml. The positive rate of rubella antibody was 78.06% and the GMC was 146.10IU / ml. Mumps antibody positive rate was 74.92%, GMC was 447.96U / ml. The positive rate of measles and rubella antibody was not statistically different in different counties, ages, sex, urban and rural areas. The positive rate of mumps antibody in urban and rural areas was not statistically different among different counties and districts, There were significant differences between the sexes (X ~ 2 = 9.760, P <0.05; X ~ 2 = 36.509, P <0.05; X ~ 2 = 5.575, P < The positive rate and low GMC, 20 to 29 age group measles, rubella antibody positive rate and GMC is not high. Conclusion The whole population of Zhaoqing City has established a certain immune barrier against measles, rubella and mumps diseases. However, preventive vaccination work should be strengthened for young children and timely vaccination of measles and rubella combined with attenuated live vaccine for children aged 8-11 months MR), children over 1.5 years of age were vaccinated with MMR; MMR was recommended for women of childbearing age from 20 to 29 years old to further improve the disease-prevention level in the whole population.