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目的探讨溃疡性结肠炎合并阿米巴肠病的临床特点。方法回顾性分析2003～2010年共104例溃疡性结肠炎患者诊治资料,其中15例确诊合并阿米巴肠病(A组),单纯性溃疡性结肠炎患者89例(B组),统计各患者的腹泻次数、贫血程度、低白蛋白血症程度及结肠病变范围。结果 A、B组患者中腹泻>6次/d者分别为13例、40例,血红蛋白<90 g/L患者分别为8例、16例,血清蛋白<30 g/L患者分别为10例、23例,结肠病变范围超过1/2的患者分别为12例、31例,两组存在统计学差异;15例溃疡性结肠炎合并阿米巴肠病患者中7例为先确诊溃疡性结肠炎,后获得阿米巴感染并致病,其余8例患者无法判断两种疾病的发病先后顺序。所统计病例中溃疡性结肠炎并发阿米巴肠病发病率为14.4%(15/104),高于阿米巴肠病在普通人群中发病率(同地区平均为0.44%,最高2.43%)。结论溃疡性结肠炎合并阿米巴肠病病情较单纯性溃疡性结肠炎患者严重;溃疡性结肠炎患者较普通人群更容易获得溶组织内阿米巴感染并致病。
Objective To investigate the clinical features of ulcerative colitis with amoebic bowel disease. Methods The clinical data of 104 patients with ulcerative colitis from 2003 to 2010 were analyzed retrospectively. Among them, 15 were diagnosed with amoebic enteropathy (group A) and 89 patients with simple ulcerative colitis (group B) The number of diarrhea patients, anemia, hypoalbuminemia and colonic lesions. Results In group A and group B, there were 13 cases of diarrhea> 6 times / d, 40 cases, 8 cases of hemoglobin <90 g / L, 16 cases, 10 cases of serum protein <30 g / 23 cases of colorectal lesions over 1/2 of the patients were 12 cases, 31 cases, there was a statistically significant difference between the two groups; 15 cases of ulcerative colitis with amoebic bowel disease in patients with first diagnosis of ulcerative colitis , Acquired amoebic infection and pathogenic disease, the remaining 8 patients can not determine the order of onset of the two diseases. The incidence of ulcerative colitis complicated with amoebic enteropathy was 14.4% (15/104) in the statistical cases, which was higher than the incidence of amoebic enteropathy in the general population (same region as 0.44% and highest 2.43%) . Conclusions Ulcerative colitis with amebic enteropathy is more serious than simple ulcerative colitis. Patients with ulcerative colitis are more likely to acquire Entamoeba histolytica infection and cause disease than the general population.