红霉素(Erythromycin,下简称EM)是临床广泛使用的大环内酚类(macrolides)抗生素,其抗菌谱与青霉素类似而稍广。EM在一般浓度时呈抑菌作用,高浓度时也呈杀菌作用。临床上EM与其它药物合并使用的情况极为常见,本文将国内外有关资料作一综合,供临床用药参考。 1.与氨茶碱的合用有些作者认为在服用EM期间茶碱血浓度的增加是病理生理或感染的结果,而不是相互作用,但在无感染者则是药物的结果。但更多的临床研究和病例报告表明EM可降低茶碱的清 Erythromycin (EM) is a clinically widely used macrolides antibiotic with a similar and slightly broader antimicrobial spectrum than penicillin. EM in the general concentration was bacteriostatic, also showed high concentrations of bactericidal effect. Clinical EM combined with other drugs is extremely common situation, this article will be a comprehensive domestic and international information for clinical reference. 1. Combination with aminophylline Some authors believe that the increase in theophylline concentration during the EM period is the result of pathophysiology or infection, rather than an interaction, but in the absence of infection is the result of the drug. However, more clinical studies and case reports indicate that EM can reduce theophylline clearance