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目的:探讨米非司酮联合甲氨蝶呤治疗输卵管妊娠的疗效。方法:选取2010年6月～2011年6月我院的40例输卵管妊娠患者为研究对象,随机分为2组,观察组20例给予MTX50mg/m2肌内注射,同时米非司酮100mg口服;对照组20例单纯给予MTX50mg/m2肌内注射,定期行尿妊娠试验、血清β-HCG值及阴道B超检查。结果:治愈率观察组85%,对照组70%。观察组血清β-HCG值下降到正常水平及包块缩小所需的时间均比对照组短,差异有统计学意义(P<0.05)。结论:米非司酮联合甲氨蝶呤治疗输卵管妊娠的疗效显著,值得临床推广应用。
Objective: To investigate the efficacy of mifepristone combined with methotrexate in the treatment of tubal pregnancy. Methods: Forty patients with tubal pregnancy in our hospital from June 2010 to June 2011 were randomly divided into two groups. MTX 50 mg / m2 was given intramuscularly in the observation group and 100 mg of mifepristone orally. Control group of 20 patients were given MTX50mg / m2 intramuscular injection, regular urinary pregnancy test, serum β-HCG value and vaginal B-ultrasound. Results: The cure rate was 85% in the observation group and 70% in the control group. The serum level of β-HCG in the observation group decreased to the normal level and the time needed to shrink the mass was shorter than that in the control group (P <0.05). Conclusion: The efficacy of mifepristone combined with methotrexate in the treatment of tubal pregnancy is significant and worthy of clinical application.