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目的：建立小鼠颌下腺纤维肉瘤肺转移模型，并观察其生物学特性。方法：应用诱发的小鼠颌下腺纤维肉瘤传代细胞，分别以２×１０６／０．２ｍｌ及１×１０６／０．２ｍｌ单细胞悬液经尾静脉接种给ＢＡＬＢ／Ｃ小鼠和ＢＡＬＢ／Ｃｎｕ／ｎｕ裸鼠。结果：接种后４周ＢＡＬＢ／Ｃ小鼠肺内可见散在、较均匀分布的转移瘤结节，位于肺表面及其实质内，数目多，呈粟粒状，转移率达１００％。ＢＡＬＢ／Ｃｎｕ／ｎｕ裸鼠转移灶出现距接种时间稍长、数目较少、大小不等，转移率为５０％。结论：本研究建立的纤维肉瘤肺转移模型方法简洁，重复性好，成功率高。为研究肺转移的机理和防治提供了一种良好的实验动物模型。
OBJECTIVE: To establish a model of lung metastasis of mouse submandibular gland fibrosarcoma and observe its biological characteristics. METHODS: Subcultured mouse submandibular gland fibrosarcoma cells were used to inoculate BALB/C mice and BALB/Cnu/nu with 2×106/0.2 ml and 1×106/0.2 ml single cell suspensions via the tail vein, respectively. Nude mice. RESULTS: In the lungs of BALB/C mice at 4 weeks after inoculation, scattered and evenly distributed metastatic nodules were seen, located on the surface of the lungs and their parenchyma. The numbers were numerous and miliary. The metastasis rate was 100%. The BALB/Cnu/nu nude mice metastasis appeared to be slightly longer, less in number, and different in size from the time of inoculation, and the metastasis rate was 50%. Conclusion: The fibrosarcoma lung metastasis model established in this study is simple, reproducible and has a high success rate. It provides a good experimental animal model for studying the mechanism and prevention of lung metastasis.