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日前,来自华盛顿大学的科学家们在《自然》杂志上报告称,他们发现,结核致病菌在上呼吸道中似乎掩盖了自身的身份,避免了被感染杀伤细胞识别。细菌召唤肺脏深层区域更能容许其感染的白细胞,搭乘它们的便车进入到了宿主身体内。研究人员指出,这项最新研究对长期以来观察到的结核感染开始于相对无菌的肺下部这一现象提供了一种解释。在上呼吸道中,居住着的细菌以及吸入的各种各样的微生物都会发送信号显示它们的存在。这些信号会向许多抗感染细胞发出警报并吸引它们到达上呼吸道。上呼吸道中存在的其他微生物有可能通过构建出一种不利的环境抑制了结核感染。
Recently, scientists from the University of Washington reported in the journal Nature that they found that tuberculosis pathogens appeared to mask their identity in the upper respiratory tract, avoiding identification by infected killer cells. Bacteria summon the white blood cells in the deeper areas of the lungs to more tolerate their infection and take their buggy into the body of the host. The researchers point out that this latest study provides an explanation for the long-observed phenomenon that tuberculosis infection starts in a relatively sterile lower lung. In the upper respiratory tract, resident bacteria and various inhaled microorganisms send signals to show their presence. These signals alert many anti-infective cells and attract them to the upper respiratory tract. Other microorganisms present in the upper respiratory tract may inhibit tuberculosis infection by creating a hostile environment.