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目的 探讨副结核杆菌（ＭＰ）在克隆病（ＣＤ）病因学中的作用。方法 将ＭＰ接种地鼠。诱导肉芽肿性肠炎动物模型，然后用一部分ＣＤ肠粘膜匀浆作ＰＣＲ扩增ＭＰ，另一部分肠壁接种地鼠。结果 ＭＰ接种８ 月后，有８０％ （１６／２０）出现肉芽肿性改变，ＰＣＲ阳性ＣＤ匀浆肠壁接种４月后，有５ 只出现肉芽肿性改变，与ＭＰ组的病理改变相似。ＰＣＲ阴性ＣＤ匀浆组有一只出现肉芽肿性改变。结论 ＭＰ可能为部分ＣＤ的致病菌，但并非唯一的致病因素
Objective To investigate the role of Mycobacterium tuberculosis (MP) in the etiology of Crohn’s disease. Methods Mice were inoculated with MP. The animal model of granulomatous enteritis was induced, and then part of the intestinal mucosa of CD was used for PCR amplification of MP. The other part of intestinal wall was inoculated with gopher. Results 80% (16/20) granulomatous changes occurred in 80% (16/20) mice after MP inoculation, and 5 cases showed granulomatous changes after 4 months inoculation of PCR positive CD homogenate, which was similar to the pathological changes in MP group. One of the PCR negative CD homogenates showed granulomatous changes. Conclusion MP may be part of CD pathogens, but not the only causative agent