对８８例乳腺癌作了ＡｇＮＯＲ银染计数及ｃ─ｅｒｂＢ─２癌蛋白的免疫组化研究。结果发现ｃ─ｅｒｂＢ─２阳性者，病死率大于ｃ─ｅｒｂＢ─２阴性者（Ｐ＜０．０１）；ＡｇＮＯＲ计数＞５者，病死率大于ＡｇＮｏＲ≤５者（Ｐ＜０．０１），表明了这两个指标对预后具有明显的价值。同时发现ＡｇＮＯＲ值＞４者，ｃ─ｅｒｂＢ─２阳性率显著高于ＡｇＮＯＲ≤４者（Ｐ＜０．０５），表明这两个指标之间也有一定的关系。我们还发现ｃ─ｅｒｂＢ─２阳性、ＡｇＮＯＲ值＞５者，病死率显著大于ｃ─ｅｒｂＢ─２阴性、ＡｇＮＯＲ值≤５者组。 AgNOR silver staining and c-erbB-2 oncoprotein immunohistochemistry were performed in 88 cases of breast cancer. The results showed that c-erbB-2 positive patients, mortality was greater than c-erbB-2 negative (P <0.01); AgNOR count> 5, mortality was greater than AgNoR <5 (P <0.01), indicating that These two indicators have obvious value for the prognosis. At the same time, we found that the positive rate of c-erbB-2 in AgNOR>4 was significantly higher than that in AgNOR≤4 (P<0.05), indicating that there was a certain relationship between these two indexes. We also found that c-erbB-2 positive and AgNOR values> 5 were significantly higher than the c-erbB-2 negative and AgNOR values ​​<5.