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目的观察三维适形放疗联合卡培他滨治疗Ⅱ、Ⅲ期直肠癌术后复发的临床疗效及不良反应。方法选取2010年3月至2013年9月许昌市人民医院收治的90例Ⅱ、Ⅲ期直肠癌患者为研究对象,将其随机分为对照组和研究组。对照组45例给予三维适形放疗,研究组45例给予三维适形放疗联合卡培他滨治疗,对比两组患者的临床效果。结果研究组总有效率为77.8%,明显优于对照组的57.8%,两组对比差异有统计学意义(P<0.05)。结论三维适形放疗联合卡培他滨治疗Ⅱ、Ⅲ期直肠癌术后复发具有良好的临床疗效,且不良反应不明显,适合临床推广和应用。
Objective To observe the clinical efficacy and adverse reactions of three-dimensional conformal radiotherapy combined with capecitabine in the treatment of postoperative recurrence of stage Ⅱ and Ⅲ rectal cancer. Methods Ninety patients with stage Ⅱ and Ⅲ colorectal cancer who were treated in Xuchang People’s Hospital from March 2010 to September 2013 were selected as study subjects and randomly divided into control group and study group. Control group, 45 cases given three-dimensional conformal radiotherapy, 45 cases of study group given three-dimensional conformal radiotherapy and capecitabine treatment, the clinical effect of two groups were compared. Results The total effective rate was 77.8% in the study group, which was significantly better than 57.8% in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion Three-dimensional conformal radiotherapy combined with capecitabine has good clinical efficacy in the treatment of recurrences of stage Ⅱ and Ⅲ rectal cancer. The adverse reaction is not obvious, which is suitable for clinical application and promotion.