瘦素又称为消脂素,是主要由脂肪组织产生的一种蛋白激素,包含146个氨基酸,具有多靶器官、功能广泛等特点[1]。近年来的诸多研究[2-4]表明,瘦素可由活化的肝星状细胞分泌,其水平与慢性肝病的发生、发展、预后、临床特点等密切相关。肝硬化为临床常见疾病,以肝组织弥漫性纤维化、再生结节形成、假小叶等为主要病理生理特 Leptin, also known as cephalosporin, is a protein hormone produced mainly by adipose tissue, which contains 146 amino acids and has multiple target organs with extensive functions [1]. In recent years, many studies [2-4] showed that leptin can be secreted by activated hepatic stellate cells, and its level is closely related to the occurrence, development, prognosis and clinical features of chronic liver disease. Cirrhosis is a common clinical disease, with diffuse liver fibrosis, regenerative nodules, false lobular, etc. as the main pathophysiological