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缺血性脑损伤是一系列复杂的多环节的病理生理变化过程,其发病率、致残率及死亡率居高不下,是严重威胁人类健康的一类重大疾病。血管内皮生长因子(VEGF)又叫血管通透因子,是有效的促血管生成因子之一,通过与其受体结合促进内皮细胞增殖,加速新血管形成,增加血管通透性。缺血性脑损伤后VEGF及其受体在脑中高度表达,促进新血管生成、改善脑血流、减轻脑损伤,在血管新生中起着重要作用。文中综述了VEGF在缺血性脑损伤后血管新生中的研究进展。
Ischemic brain injury is a series of complex multi-link pathophysiological changes, its morbidity, disability and high mortality, is a serious threat to human health, a class of major diseases. Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is one of the effective pro-angiogenic factors that promote endothelial cell proliferation, accelerate new blood vessel formation and increase vascular permeability by binding to its receptor. After ischemic brain injury, VEGF and its receptors are highly expressed in the brain and promote neovascularization, improve cerebral blood flow, reduce brain damage and play an important role in angiogenesis. This review summarizes the progress of VEGF in angiogenesis after ischemic brain injury.