论文部分内容阅读
目的 了解慢性肾功能衰竭(CRF)患者外周血T淋巴细胞亚群及可溶性白细胞介素Ⅱ受体(sIL-2R)的变化及意义。方法 采用免疫细胞化学ABC间接法及双抗体夹心ELIA法进行检测。结累 ①CRF患者外周血CD_3~+,CD_4~+,CD_8~+细胞,CD_4~+/CD_8~+比值均显著低于正常对照组(P<0.05～0.01),与Scr,GFR无相关性;③血清sIL-2R含量较对照组显著增高(P<0.01),与Scr呈显著正相关。与GFR呈显著负相关。结论 CRF患者存在免疫功能异常,免疫调节剂的使用可能有助于延缓 CRF的进展。
Objective To investigate the changes of peripheral blood T lymphocyte subsets and soluble interleukin-2 receptor (sIL-2R) in patients with chronic renal failure (CRF) and its significance. Methods Immunocytochemistry ABC indirect method and double antibody sandwich ELIA method for detection. (1) The ratio of CD_3 ~ +, CD_4 ~ +, CD_8 ~ + and CD_4 ~ + / CD_8 ~ + in the peripheral blood of CRF patients were significantly lower than that of the normal control group ③ Serum sIL-2R level was significantly higher than that of the control group (P <0.01), and was positively correlated with Scr. There was a significant negative correlation with GFR. Conclusion CRF patients have abnormal immune function. The use of immunomodulatory agents may help to delay the progress of CRF.