mToR是一种在细胞生长调控中处于核心地位的丝/苏氨酸蛋白酶。其相关信号通路复杂,且涉及面广泛,mToR可在多种因素的活化下参与基因转录、蛋白质翻译起始、核糖体生物合成、细胞凋亡等多项细胞功能。大量研究显示:mTOR信号通路调控异常与肿瘤发生密切相关,是肿瘤治疗的一个重要靶点。 mToR is a silk / threonine protease that is central to cell growth regulation. Its related signaling pathway is complex and involves a wide range of aspects, mToR can participate in a number of cellular functions such as gene transcription, initiation of protein translation, ribosomal biosynthesis and apoptosis under the activation of many factors. Numerous studies have shown that: abnormal regulation of mTOR signaling pathway is closely related to tumorigenesis, which is an important target of tumor therapy.