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早幼粒白血病蛋白核体(promyelocytic leukaemia nuclear bodies,PML-NBs)是哺乳动物细胞中普遍存在的一种动态的细胞核亚结构,参与DNA损伤与修复、细胞衰老与凋亡、基因表达调控以及肿瘤发生与抑制等多种重要的细胞活动。研究表明,PML-NBs也是多种病毒入侵细胞的作用靶点。PML-NBs通过介导细胞固有免疫反应或者作为细胞干扰素信号通路元件参与宿主细胞的抗病毒防御活动。该文以几种DNA和RNA病毒为例,综述了在病毒感染过程中PML-NBs与病毒的相互作用以及这些相互作用的功能意义,从而揭示PML-NBs在抵御病毒感染和免疫反应中的重要作用,并提出运用病毒单分子实时示踪(Single-virus Tracking)这一新技术深入研究PML-NBs在病毒感染中作用的可行性。
Promyelocytic leukemia nuclear bodies (PML-NBs) are ubiquitous dynamic nuclear sub-structures in mammalian cells. They are involved in DNA damage and repair, cell senescence and apoptosis, gene expression regulation, and tumor Occurrence and inhibition of a variety of important cell activities. Studies have shown that, PML-NBs is also a variety of viral invasion target cells. PML-NBs participate in antiviral defense activities of host cells by mediating cellular innate immune responses or as interferon signaling elements. In this paper, taking several DNA and RNA viruses as an example, the interaction between PML-NBs and viruses during virus infection and the functional significance of these interactions are reviewed to reveal the importance of PML-NBs in combating viral infections and immune responses And proposed the use of single-virus single-virus tracking of the virus technology in-depth study of the feasibility of PML-NBs in the role of virus infection.