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目的观察产程活跃期使用间苯三酚促宫颈口扩张,加速产程进展的作用。方法选择2008年1月—2010年12月住院分娩的足月妊娠的单胎头位初产妇,宫口开大≥3 cm伴宫颈质韧或水肿者185例随机分成A、B、C 3组:A组(62例)在产程活跃期静脉注射间苯三酚80 mg,B组(63例)在产程活跃期静脉缓慢注射654-2 10 mg,C组(60例)在产程活跃期静脉缓慢注射地西泮10 mg(>5 min)促宫颈口扩张,观察3组产程进展、分娩方式、胎儿宫内窘迫、新生儿Apgar评分及产后出血情况。结果间苯三酚组用药至宫口开全时间为(3.4±1.2)h,第1产程平均时间为(8.2±1.7)h,明显短于654-2组与地西泮组,差异有统计学意义(P<0.05)。结论产程活跃期使用间苯三酚可消除宫颈水肿,促宫口扩张,加速产程进展,效果优于654-2及地西泮,而且对母儿无不良影响。
Objective To observe the role of phloroglucinol in promoting cervical os dilation and accelerating the progress of labor in active stage of labor. Methods 185 cases of single-head primipara, full-mouth greater than 3 cm with cervical stricture or edema of full-term pregnancy hospitalized for delivery from January 2008 to December 2010 were randomly divided into A, B and C groups : Group A (62 cases) received intravenous injection of phloroglucinol 80 mg in the active phase of labor, and group B (63 cases) received 654-2 10 mg intravenously in the active phase of labor during the labor cycle. Group C (60) Slow injection of diazepam 10 mg (> 5 min) to promote cervix dilatation, labor progress, mode of delivery, fetal distress, neonatal Apgar score and postpartum hemorrhage were observed. Results The duration of the treatment of phloroglucinol to cervix was (3.4 ± 1.2) h and the average duration of the first stage of labor was (8.2 ± 1.7) h, which was significantly shorter than that of the 654-2 group and the diazepam group Significance (P <0.05). Conclusion The active phase of labor with phloroglucinol can eliminate cervical edema, uterine cervix expansion and accelerate the progress of labor, the effect is better than 654-2 and diazepam, but no adverse effects on the mother and child.