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目的:探讨血清神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)及胃泌素释放肽前体(ProGRP)3项肿瘤标志物对肺肿瘤患者的诊断价值。方法:选取临床资料无显著差异的患者180例,将其分为2组,A组100例为患肺部良性病变的患者,B组80例为病理证实的肺肿瘤患者。另选取同期健康志愿者100例作为对照组。检测3组NSE、CYFRA21-1、ProGRP水平,比较3项指标的单项检测与3项联合检测对肺肿瘤诊断的敏感度、特异度、准确性。结果:B组肺肿瘤患者3项指标均高于其他2组(P<0.05);血清NSE、ProGRP水平对小细胞肺肿瘤患者的检测结果较高,CYFRA21-1对鳞状细胞癌患者的检测结果较高;联合检测诊断肺肿瘤的灵敏度、特异度以及准确性较单项检测更高;血清NSE、ProGRP水平对小细胞肺肿瘤检测灵敏度较高,CYFRA21-1对鳞状细胞癌患者检测灵敏度较高。结论:NSE、CYFRA21-1、ProGRP检测可用于肺肿瘤诊断、鉴别诊断及病理分型,联合检测诊断可提高肺肿瘤诊断准确率。
Objective: To investigate the diagnostic value of three tumor markers of serum neuron-specific enolase (NSE), cytokeratin 19 (CYFRA21-1) and proGRP (ProGRP) in patients with lung cancer. Methods: One hundred and eighty patients with no significant difference in clinical data were selected and divided into two groups: 100 patients in group A were patients with benign lung disease and 80 patients in group B were pathologically confirmed lung cancer patients. Another 100 healthy volunteers were selected as the control group. The levels of NSE, CYFRA21-1 and ProGRP in 3 groups were detected. The sensitivity, specificity and accuracy of single test and 3 combined test on lung cancer were compared. Results: Three indexes of lung cancer patients in group B were higher than those in other two groups (P <0.05). Serum levels of NSE and ProGRP were higher in patients with small cell lung cancer and CYFRA21-1 in patients with squamous cell carcinoma The sensitivity, specificity and accuracy of the combined detection of lung cancer were higher than that of single detection. The sensitivity of serum NSE and ProGRP in detecting small cell lung cancer was high. The detection sensitivity of CYFRA21-1 in patients with squamous cell carcinoma was higher high. Conclusion: The detection of NSE, CYFRA21-1 and ProGRP can be used for the diagnosis, differential diagnosis and pathological classification of lung tumors. Combined detection and diagnosis can improve the diagnostic accuracy of lung tumors.