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氨基膦酸生物活性的发现,推动了这类氨基磷酸类似物合成方法的研究。我们曾仔细考察过在醛、羰酰胺与亚磷酸酯的反应中,试剂结构的改变对产物得率的影响,并提出此反应系基于亚磷酸酯对甲基亚胺衍生物的
The discovery of aminophosphonic acid biological activity has promoted the synthesis of such phosphoramidate analogues. We have carefully examined the effect of changes in the structure of the reagents on the yields of the aldehydes, carboxamides and phosphites, and suggested that this reaction be based on the reaction of the phosphite with the methylimine derivative