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报道了125I标记的15－（对－碘苯）3－（R，S）－甲基－十五烷酸（BMIP）在SD鼠体内的分布以及血流改变对其在心肌中分布的影响。结果显示，SD鼠心肌摄取125I－BMIPP在5min时为3．86％ID／g，且5－60min保持稳定；30min时心／血、心／肺、心／肝比值分别为1．56、2．08和1．62，而125I－BMIPP在肝脏中的清除则较快。对照组心肌摄取125I－BMIPP及心／血比值分别为3．27±0．32％ID／g和1．56±0．09；与正常对照组相比，双嘧达莫组心肌对125I－BMIPP摄取（3．90±0．25％ID／g）及心／血比值（1．79±0．17）明显增高（P＜0．05）。表明BMIPP在心肌中的滞留时间较长且能反映心肌的血流灌注，故BMIPP可作为心肌瘤注示踪剂而适宜于SPECT显像。
The distribution of 125I-labeled 15- (p-iodobenzene) 3- (R, S) -methyl-pentadecanoic acid (BMIP) in SD rats and the effect of blood flow changes on myocardial distribution were reported. The results showed that the uptake of 125I-BMIPP in SD rats was 3.86% ID / g at 5 min, and remained stable at 5-60 min. The heart / blood, heart / lung and heart / liver ratios were 1.56 and 2 .08 and 1.62, whereas 125I-BMIPP cleared faster in the liver. The myocardial uptake of 125I-BMIPP and the ratio of heart / blood in the control group were 3.27 ± 0.32% ID / g and 1.56 ± 0.09, respectively. Compared with the normal control group, BMIPP uptake (3.90 ± 0.25% ID / g) and heart / blood ratio (1.79 ± 0.17) were significantly higher (P <0.05). BMIPP showed that myocardial retention in myocardial longer and can reflect the myocardial perfusion, so BMIPP can be used as a cardiomyopathy tracer and suitable for SPECT imaging.