论文部分内容阅读
目的分析慢性轴索性多发神经病的临床特点、病因构成及预后情况。方法收集2006年1月至2011年6月在天坛医院神经内科住院的81例慢性轴索性多发性神经病患者,回顾性分析其临床特点及病因诊断;以总体残疾评分总和(overall disability scale score,ODSS)评价疾病残疾程度,对部分患者进行随访。结果 81例多发性神经病患者平均年龄52岁,男∶女为49∶32。病因共10种:纯感觉性神经病34例,病因以中毒代谢为主;感觉运动性神经病46例,以免疫介导性多见(χ2=19.35 P=0.000);纯运动性1例;合并颅神经病变10例。共随访51例,预后良好40例,恶化10例,包括死亡5例。结论慢性轴索性多发性神经病病因构成复杂,本组病例最多见的是中毒代谢、免疫介导性、病因不明(chronic idiopathic axonal polyneuropathy,CIAP)。80%经病因治疗临床预后较好,但部分病因可导致严重残障甚至死亡。
Objective To analyze the clinical features, etiology and prognosis of chronic axonal polyneuropathy. Methods Totally 81 patients with chronic axonal polyneuropathy hospitalized in Department of Neurology, Tiantan Hospital from January 2006 to June 2011 were retrospectively analyzed for their clinical features and etiological diagnosis. The overall disability scale score (ODSS ) Evaluation of disease disability, some patients were followed up. Results The average age of 81 patients with polyneuropathy was 52 years old, male to female 49:32. Etiology of a total of 10 kinds: pure sensory neuropathy in 34 cases, the main cause of toxic metabolism; sensory motor neuropathy in 46 cases, immune-mediated more common (χ2 = 19.35 P = 0.000); pure motor in 1 case; Neuropathy in 10 cases. A total of 51 cases were followed up with 40 cases of good prognosis and 10 cases of worsening, including 5 cases of death. Conclusion The causes of chronic axonal polyneuropathy are complicated. The most common group of patients with chronic axonal polyneuropathy is poisoning, immune-mediated and unidentified (idiopathic axonal polyneuropathy). 80% of the clinical prognosis of the cause of treatment is better, but some causes can lead to serious disability or even death.