论文部分内容阅读
99例经内镜证实的十二指肠球部溃疡(DU)患者,以单盲方式随机分成三组,每组33例。三组每日分别晨8时服奥美拉唑10mg、20mg和40mg。所有患者均在治疗前后第五天分别作24小时胃内持续的pH监护观察。治疗4周后作内镜复查以确定溃疡是否愈合。结果示:三组胃内pH值均较服药前有显著的增高(P<0.001)。奥美拉唑10mg组,42％患者胃内pH>3的持续时间超过16小时,28％超过8小时,
Ninety-nine patients with endoscopic duodenal ulcer (DU) were randomly divided into three groups (33 in each group). Omeprazole 10 mg, 20 mg and 40 mg were administered to the three groups daily at 8 o’clock in the morning. All patients were treated for 24 hours on the fifth day before and after treatment with continuous intragastric pH monitoring. After 4 weeks of treatment, endoscopy was performed to determine if the ulcer healed. The results showed that: three groups of stomach pH value was significantly higher than before treatment (P <0.001). In the omeprazole 10 mg group, 42% of patients had a gastric pH> 3 for a duration of more than 16 hours, 28% for more than 8 hours,