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目的:调查梅毒流行病学特征,观察梅毒应用米诺环素治疗的效果。方法:选择本院2011年7月~2016年11月收治的青霉素皮试阳性结果的梅毒患者60例,收集其病历资料,分析流行病学特征,并给予米诺环素治疗,观察治疗效果。结果:梅毒流行病学特征:发病率逐年升高,多发于20~39岁人群。米诺环素治疗效果:硬下疳消退时间(7.3±0.6)d;玫瑰疹及掌跖梅毒疹消退时间(11.5±1.8)d;扁平湿疣消退时间(12.3±1.5)d。出现不良反应12例,发生率20.0%。经治疗后,RPR转阴46例,转阴率76.7%。结论:梅毒的发病率逐渐提升,临床应用米诺环素治疗时,治疗效果较好。
Objective: To investigate the epidemiological characteristics of syphilis and observe the effect of minocycline on syphilis. Methods: 60 patients with syphilis who were positive for penicillin skin test in our hospital from July 2011 to November 2016 were selected. Their medical records were collected and their epidemiological characteristics were analyzed. The patients were treated with minocycline and the therapeutic effects were observed. Results: Epidemiological characteristics of syphilis: the incidence increased year by year, mainly in 20 to 39-year-old population. The treatment effect of minocycline was as follows: subdural gallbladder subsided time (7.3 ± 0.6) d; measles edema and palmoplantar eradication subsided time (11.5 ± 1.8) d; condyloma acuminatum subsided time (12.3 ± 1.5) d. Adverse reactions occurred in 12 cases, the incidence of 20.0%. After treatment, RPR negative in 46 cases, the negative rate of 76.7%. Conclusion: The incidence of syphilis gradually increased, the clinical application of minocycline treatment, the treatment effect is better.