用离体大鼠肝灌流方法,研究了稳态时美托洛尔的代谢模型,灌流量分别为10,20和30ml·min~(-1)时;流入肝脏的浓度分别为7.6,5.0和3.4μg·ml~(-1);流出肝脏的浓度分别为1.2,2.0和2.7μg·ml~(-1);肝窦平均浓度分别为3.4,3.2和3.0μg·ml~(-1)。提示流入和流出浓度呈流量依赖性,与‘平行管’模型相符,而与‘充分搅拌’模型不符。 Metoprolol metabolism model at steady state was studied with rat hepatic perfusion method. The perfusion rates were 10, 20 and 30 ml · min -1, respectively. The concentrations of metoprolol into the liver were 7.6, 5.0 and 3.4μg · ml ~ (-1); the outflow hepatic concentrations were 1.2, 2.0 and 2.7μg · ml ~ (-1) respectively; mean sinusoidal sinusoidal concentrations were 3.4, 3.2 and 3.0μg · ml ~ (-1) respectively. It is suggested that inflow and outflow concentrations are dose-dependent, consistent with the model of “parallel tube”, but not with the “full mixing” model.